Peptide Profile of Zebrafish Brain in a 6-OHDA-Induced Parkinson Model
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چکیده
منابع مشابه
Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease.
Stem cell-based therapy is a promising treatment for neurodegenerative diseases. In our laboratory, a novel protocol has been developed to induce bone marrow-derived mesenchymal stem cells (MSC) into neurotrophic factors- secreting cells (NTF-SC), thus combining stem cell-based therapy with the NTF-based neuroprotection. These cells produce and secrete factors such as brain-derived neurotrophic...
متن کاملProtective Effects of Neurotrophic Factors-Secreting Cells in a 6-OHDA Rat Model of Parkinson Disease
1 Laboratory of Neurosciences, Felsenstein Medical Research Center, Department of Neurology, Rabin Medical Center, Sackler Faculty of Medicine, and 4School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel. 2 Brainstorm Cell Therapeutics Ltd., Petah-Tikva, Israel. 3 Department of Hematology, Laniado Medical Center, Natanya, Israel. Pr...
متن کاملCharacterizing the Modulation of mGluR 5 in a 6 - OHDA - induced Rat Model of Parkinson ' s Disease
MicroPET imaging studies were conducted to investigate the role of metabotropic glutamate subtype-5 receptors (mGluR5) in Parkinson's disease (PD). Four analogical PET ligands were used to characterize modulation of mGluR5 function in a 6hydroxydopamine (6-OHDA) induced rat model of PD. Unilateral 6-OHDA lesions were made in the right medial forebrain bundle, and severity of these lesions was d...
متن کاملThe Protective Effects of Citrus Aurantium Extract in A 6-Hydroxydopamine-Induced Model of Parkinson\'s Disease in Male Rats
Introduction: Parkinson's disease (PD) is a commonly diagnosed neurodegenerative disease among the elderly. Considering the limited symptomatic improvement associated with PD treatments, introduction of more effective agents is necessary. Citrus aurantium flower extract (CAE) is recognized as a neuroprotective and hepatoprotective agent with bioactive compounds, such as flavonoids, phenolics, a...
متن کاملNeuroprotective effect of BDNF in young and aged 6-OHDA treated rat model of Parkinson disease.
Brain derived neurotrophic factor (BDNF) has been shown to exert trophic effects on dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in young rat. Since the degeneration of substantia nigra dopaminergic neurons that occurs in Parkinson's disease is more often than not confined to elderly individuals, it is of interest to determine whether the effects of BDNF against 6 hydroxydopamine (6-...
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ژورنال
عنوان ژورنال: Zebrafish
سال: 2021
ISSN: 1545-8547,1557-8542
DOI: 10.1089/zeb.2020.1945